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The Ultimate Guide to Grubbs’ Catalyst 2nd Generation CAS 246047-72-3 MSDS & Safety Protocols

 Grubbs’ Catalyst 2nd Generation (CAS 246047-72-3) is a powerful tool for organic synthesis, but its air-sensitive nature and chemical reactivity require strict safety protocols. In this guide, we’ll walk you through the Material Safety Data Sheet (MSDS), essential safety measures, and best practices for handling this catalyst. Whether you’re a lab manager or researcher, this guide will help you ensure compliance and protect your team.

Why Safety Matters

1. Health Risks

Grubbs’ Catalyst can cause:

  • Skin and eye irritation upon contact.
  • Respiratory issues if inhaled.
  • Toxicity if ingested.

2. Fire and Explosion Hazards

  • The catalyst is air-sensitive and can ignite upon exposure to moisture or oxygen.
  • Ruthenium complexes are flammable and require inert handling.

3. Regulatory Compliance

  • OSHA, REACH, and GHS regulations mandate proper handling, storage, and disposal.
  • Non-compliance can result in fines, legal action, or lab shutdowns.

Key Sections of the MSDS

1. Product Identification

  • CAS Number: 246047-72-3.
  • Chemical Name: Bis(tricyclohexylphosphine)benzylidene ruthenium(IV) dichloride.
  • Supplier Information: KiloBio.

2. Hazard Identification

  • Health Hazards: Irritant, toxic if ingested.
  • Fire Hazards: Flammable, air-sensitive.
  • Environmental Hazards: Toxic to aquatic life.

3. Composition/Ingredients

  • Ruthenium Content: 20–25%.
  • Stabilizers: Inert gas (argon) for packaging.

4. First-Aid Measures

  • Skin Contact: Wash with soap and water.
  • Eye Contact: Rinse with water for 15 minutes.
  • Inhalation: Move to fresh air.
  • Ingestion: Seek medical attention immediately.

5. Fire-Fighting Measures

  • Extinguishing Media: Dry chemical, CO2, or sand.
  • Special Precautions: Use self-contained breathing apparatus (SCBA).

6. Accidental Release Measures

  • Spill Response: Evacuate area, contain spill, and collect in a sealed container.
  • Disposal: Follow local regulations for hazardous waste.

7. Handling and Storage

  • Handling: Use in a fume hood with gloves and goggles.
  • Storage: Store at -20°C under argon in amber vials.

8. Exposure Controls/Personal Protection

  • Ventilation: Use fume hoods or glove boxes.
  • PPE: Lab coat, gloves, safety goggles, and SCBA if necessary.

9. Physical and Chemical Properties

  • Appearance: Dark brown solid.
  • Solubility: Soluble in organic solvents (e.g., dichloromethane).
  • Stability: Air-sensitive, stable under argon.

10. Toxicological Information

  • Acute Toxicity: LD50 (oral, rat) > 2000 mg/kg.
  • Chronic Effects: Prolonged exposure may cause respiratory issues.

11. Ecological Information

  • Aquatic Toxicity: Toxic to fish and invertebrates.
  • Persistence: Non-biodegradable.

12. Disposal Considerations

  • Waste Disposal: Follow local regulations for hazardous waste.
  • Recycling: Recover ruthenium if possible.

13. Transport Information

  • UN Number: 3082 (Environmentally Hazardous Substances).
  • Packaging Group: II.

14. Regulatory Information

  • OSHA: Hazardous chemical.
  • REACH: Registered under Annex XIV.

15. Other Information

  • Shelf Life: 24 months under proper storage.
  • Technical Support: Contact KiloBio for assistance.

Best Practices for Safe Handling

1. Use Proper PPE

  • Wear gloves, safety goggles, and a lab coat at all times.
  • Use SCBA for large-scale handling.

2. Work in a Fume Hood

  • Prevent exposure to fumes or dust.
  • Ensure proper ventilation.

3. Store Under Inert Conditions

  • Keep catalyst in argon-sealed vials at -20°C.
  • Avoid exposure to air or moisture.

4. Train Your Team

  • Conduct regular safety training sessions.
  • Keep MSDS documents accessible.

Why KiloBio is the Top Choice

✅ Certified Quality Assurance

  • Purity: ≥99% (HPLC-verified).
  • Packaging: Sealed under argon in amber vials.
  • CoA: Batch-specific documentation included.

✅ Transparent Pricing

No hidden fees. Our bulk rates start at $165/gram (100g+ orders).

✅ Fast Global Shipping

Guaranteed delivery in 5–7 days to the US, EU, and Asia.

Frequently Asked Questions

Q: Where can I download the MSDS for Grubbs’ Catalyst 2nd Generation?

A: Request the MSDS from your supplier. KiloBio provides batch-specific MSDS with every order.

Q: How do I dispose of expired catalyst?

A: Follow local hazardous waste regulations. Contact KiloBio for guidance.

Q: Do you offer technical support for safe handling?

A: Yes – our team is available 24/7 for troubleshooting and safety advice.

Ready to Ensure Safety in Your Lab?

Don’t compromise on safety or quality. Click here to request a quote for Grubbs’ Catalyst 2nd Generation (CAS 246047-72-3). With certified quality and unbeatable pricing, your next breakthrough is just an inquiry away.

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