Grubbs’ Catalyst 2nd Generation (CAS 246047-72-3) and Hoveyda-Grubbs Catalyst are two of the most widely used catalysts for olefin metathesis and ring-opening polymerization (ROMP). But which one offers the best cost-performance ratio for your lab? In this post, we’ll compare their prices, efficiency, and long-term savings to help you make an informed decision.
Key Differences at a Glance
| Feature | Grubbs’ Catalyst 2nd Gen | Hoveyda-Grubbs Catalyst |
|---|---|---|
| Price/Gram | 165–165–220 | 180–180–240 |
| Reaction Efficiency | High (95% yield) | High (90% yield) |
| Substrate Tolerance | Broad | Broad |
| Shelf Life | 24 months | 18 months |
| Ease of Handling | Air-sensitive | Air-stable |
Cost Comparison: Grubbs’ Catalyst 2nd Generation vs. Hoveyda-Grubbs
1. Upfront Costs
- Grubbs’ Catalyst 2nd Gen: 165–165–220/gram (bulk discounts available).
- Hoveyda-Grubbs Catalyst: 180–180–240/gram.
Winner: Grubbs’ Catalyst 2nd Generation offers lower upfront costs, especially for bulk orders.
2. Reaction Efficiency
- Grubbs’ Catalyst 2nd Gen: Achieves 95% yields in most reactions.
- Hoveyda-Grubbs Catalyst: Typically achieves 90% yields.
Winner: Grubbs’ Catalyst 2nd Generation provides higher yields, reducing reagent waste.
3. Catalyst Loading
- Grubbs’ Catalyst 2nd Gen: Requires 0.5–1 mol% loading.
- Hoveyda-Grubbs Catalyst: Requires 1–2 mol% loading.
Winner: Grubbs’ Catalyst 2nd Generation uses less catalyst per reaction, saving money over time.
4. Shelf Life
- Grubbs’ Catalyst 2nd Gen: Stable for 24 months when stored properly.
- Hoveyda-Grubbs Catalyst: Stable for 18 months.
Winner: Grubbs’ Catalyst 2nd Generation offers longer shelf life, reducing the need for frequent reordering.
Real-World Applications: Cost vs. Performance
1. Pharmaceuticals
- Grubbs’ Catalyst 2nd Gen: Ideal for macrocyclic drug synthesis and peptide stapling due to high yields and efficiency.
- Hoveyda-Grubbs Catalyst: Suitable for air-sensitive reactions but may require higher loadings.
2. Materials Science
- Grubbs’ Catalyst 2nd Gen: Preferred for ROMP of norbornene and functionalized cyclopentenes.
- Hoveyda-Grubbs Catalyst: Used in specialized polymerizations but at higher costs.
3. Academic Research
- Grubbs’ Catalyst 2nd Gen: Offers cost-effective experiments for grant-funded projects.
- Hoveyda-Grubbs Catalyst: May strain budgets due to higher prices and lower yields.
How to Maximize Savings with Grubbs’ Catalyst 2nd Generation
1. Bulk Purchasing
Ordering in bulk slashes costs by up to 30%. For example:
- 10–50g: $185/gram.
- 100g+: $165/gram.
2. Optimize Reaction Conditions
- Use lower catalyst loadings (0.5–1 mol%) without sacrificing yield.
- Store catalyst under argon at -20°C to extend shelf life.
3. Partner with Trusted Suppliers
Choose suppliers like KiloBio for:
- Certified Quality: ≥99% purity (HPLC-verified).
- Bulk Discounts: Competitive pricing for 100g+ orders.
- Global Delivery: Ships to 50+ countries in 5–7 days.
Why KiloBio is the Top Choice
✅ Certified Quality Assurance
- Purity: ≥99% (HPLC-verified).
- Packaging: Sealed under argon in amber vials.
- CoA: Batch-specific documentation included.
✅ Transparent Pricing
No hidden fees. Our bulk rates start at $165/gram (100g+ orders).
✅ Fast Global Shipping
Guaranteed delivery in 5–7 days to the US, EU, and Asia.
Frequently Asked Questions
Q: Is Grubbs’ Catalyst 2nd Generation worth the higher upfront cost?
A: Yes – its efficiency and lower loading requirements save 20–30% in long-term costs.
Q: Can I use Grubbs’ Catalyst 2nd Generation for air-sensitive reactions?
A: Absolutely. Store and handle it under inert conditions for optimal performance.
Q: Do you offer academic discounts?
A: Yes – universities and non-profits receive an additional 5–10% discount on bulk orders.
Ready to Save with Grubbs’ Catalyst 2nd Generation?
Don’t let high costs or inefficiencies hold back your research. Click here to request a quote for Grubbs’ Catalyst 2nd Generation (CAS 246047-72-3). With unbeatable cost-performance and certified quality, your next breakthrough is just an inquiry away.
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